Thymosin Beta 4, or TB-500, is a synthetic version of a naturally occurring 43-amino acid peptide present in nearly all human and animal cells studied. TB500 is known to stimulate myoblasts and myocytes (muscle generating cells). Mitochondrial RNA levels of TB500 have been shown to increase following muscle injury, helping to regenerate muscle fibers and address inflammation in the injured location. The data support muscle injury causing increased local production of TB500, promoting migration of incoming myoblasts to accelerate skeletal muscle regeneration.
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